Thoracic impedance detection with blood resistivity compensation

ABSTRACT

This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.

TECHNICAL FIELD

This document pertains generally to implantable medical devices and more particularly, but not by way of limitation, to congestive heart failure (CHF) thoracic fluid detection and other thoracic impedance systems, devices, or methods that compensate or correct for changes in blood resistivity.

BACKGROUND

Variations in how much fluid is present in a person's thorax can take various forms and can have different causes. Eating salty foods can result in retaining excessive fluid in the thorax and elsewhere. Posture changes can also affect the amount of thoracic fluid. For example, moving from supine to standing can shift intravascular fluid away from the thorax toward the lower extremities.

Another example is pulmonary edema, which results in buildup of extravascular fluid in the lungs. In pulmonary edema, fluid accumulates in extracellular spaces, such as the spaces between lung tissue cells. One cause of pulmonary edema is congestive heart failure (CHF), which is also sometimes referred to as “chronic heart failure,” or as “heart failure.” CHF can be conceptualized as an enlarged weakened portion of heart muscle. The impaired heart muscle results in poor cardiac output of blood. As a result of such poor blood circulation, blood tends to pool in blood vessels in the lungs. This intravascular fluid buildup, in turn, results in the extravascular fluid buildup mentioned above. In sum, pulmonary edema can be one important condition associated with CHF.

Yet another example of thoracic fluid accumulation is pleural effusion, which is the buildup of extravascular fluid in the space between the lungs and the rib cage. Pleural effusion can also result from CHF because, as discussed above, intravascular fluid buildup can result in the extravascular interstitial fluid buildup. The extravascular fluid buildup of pulmonary edema can, in turn, result in the extravascular fluid buildup of pleural effusion.

CHF may also activate several physiological compensatory mechanisms. Such compensatory mechanisms are aimed at correcting the reduced cardiac output. For example, the heart muscle may stretch to increase its contractile power. Heart muscle mass may also increase. This is referred to as “hypertrophy.” The ventricle may also change its shape as another compensatory response. In another example, a neuro-endocrine response may provide an adrenergic increase in heart rate and contraction force. The Renin-Angiotensin-Aldosterone-System (RAAS) may be activated to induce vasoconstriction, fluid retention, and redistribution of blood flow. Although the neuro-endocrine response is compensatory, it may overload the cardiovascular system. This may result in myocardial damage, and may exacerbate CHF.

Diagnosing CHF may involve physical examination, electrocardiogram (ECG), blood tests, chest radiography, or echocardiography. Managing a CHF patient is challenging. CHF may require potent drugs. Moreover, treatment may be thwarted by the compensatory mechanisms, which may recompensate for the presence of the medical treatment. Therefore, treating CHF involves a delicate balance to properly manage the patient's hemodynamic status in a state of proper compensation to avoid further degeneration.

However, this delicate balance between compensation and effective CHF treatment is easily upset, even by seemingly benign factors, such as common medication (e.g., aspirin), physiological factors, excitement, or gradual progression of the disease. This may plunge the patient into a decompensation crisis, which requires immediate corrective action so as to prevent the deterioration of the patient's condition which, if left unchecked, can lead to death. In sum, accurately monitoring the symptoms of CHF, such as thoracic fluid accumulation, is very useful for avoiding such a decompensation crisis and properly managing the CHF patient in a state of relative well-being.

BRIEF DESCRIPTION OF THE DRAWINGS

In the drawings, which are not necessarily drawn to scale, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components. The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in the present document.

FIG. 1 is a block diagram illustrating generally one example of a system that provides a thoracic fluid amount indication that is adjusted to compensate for a change in blood resistivity, if any.

FIG. 2 is a schematic illustration of one example in which portions of the system are implemented in an implantable cardiac rhythm management (CRM) or other implantable medical device (IMD).

FIG. 3 is a block diagram illustrating generally another example in which portions of the system are implemented in an implantable CRM or other IMD.

FIG. 4 is a flow chart illustrating generally one example of a method of providing a thoracic fluid amount indication that is compensated for any changes in blood resistivity.

FIG. 5 is a flow chart illustrating generally one example of a method of detecting anemia using a blood impedance measurement performed by an implantable medical device.

DETAILED DESCRIPTION

The following detailed description includes references to the accompanying drawings, which form a part of the detailed description. The drawings show, by way of illustration, specific embodiments in which the invention may be practiced. These embodiments, which are also referred to herein as “examples,” are described in enough detail to enable those skilled in the art to practice the invention. The embodiments may be combined, other embodiments may be utilized, or structural, logical and electrical changes may be made without departing from the scope of the present invention. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims and their equivalents.

In this document, the terms “a” or “an” are used, as is common in patent documents, to include one or more than one. In this document, the term “or” is used to refer to a nonexclusive or, unless otherwise indicated. Furthermore, all publications, patents, and patent documents referred to in this document are incorporated by reference herein in their entirety, as though individually incorporated by reference. In the event of inconsistent usages between this document and those documents so incorporated by reference, the usage in the incorporated reference(s) should be considered supplementary to that of this document; for irreconcilable inconsistencies, the usage in this document controls.

In this document, the term intravascular includes the term intracardiac.

In this document, the term cardiovascular includes an association with either the heart or a blood vessel.

In this document, the term “thorax” refers to a human subject's body other than the subject's head, arms, and legs.

FIG. 1 is a block diagram illustrating generally one example of a system 100 that provides an indication of the amount of fluid in the thorax (“thoracic fluid indication”) that is adjusted to compensate for a change in blood resistivity, if any.

In this example, the system 100 includes a thoracic impedance measurement circuit 102. The thoracic impedance measurement circuit 102 receives at least one electrical signal from electrodes associated with a patient's thorax. This electrical signal is typically received in response to a test energy applied to the thorax, such as by a thoracic impedance test energy delivery circuit 104.

One illustrative example of some electrode configurations and circuits for performing thoracic impedance measurements is described in Hartley et al. U.S. Pat. No. 6,076,015 entitled RATE ADAPTIVE CARDIAC RHYTHM MANAGEMENT DEVICE USING TRANSTHORACIC IMPEDANCE, which is assigned to Cardiac Pacemakers, Inc., and which is incorporated herein by reference in its entirety, including its description of performing thoracic impedance measurements. The Hartley et al. U.S. Pat. No. 6,076,015 uses thoracic impedance to obtain a respiration signal. By contrast, the present patent application uses thoracic impedance to obtain a thoracic fluid status signal. Therefore, the signal of interest in the present patent application would be deemed noise in the Hartley et al. U.S. Pat. No. 6,076,015, and vice-versa. However, both thoracic fluid status and respiration are obtainable using the thoracic impedance detection techniques described in the Hartley et al. U.S. Pat. No. 6,076,015. The present thoracic fluid status signal of interest is obtained from a lower frequency (i.e., a “near-DC”) portion of the thoracic impedance signal rather than the frequencies of the respiration signal described in the Hartley et al. U.S. Pat. No. 6,076,015. In this document, the “near-DC” component of the thoracic impedance signal refers to the frequencies below which respiration and cardiac contractions significantly influence the thoracic impedance signal. This near-DC component of the thoracic impedance signal, therefore, typically refers to signal frequencies below a cutoff frequency having a value of about 0.1 Hz, such as at signal frequencies between about 5×10⁻⁷ Hz and 0.05 Hz, because the cardiac stroke and respiration components of the thoracic impedance signal lie at higher frequencies. Fluid accumulation in the thorax corresponds to a decrease in the near-DC thoracic impedance. Conversely, fluid depletion in the thorax corresponds to an increase in the near-DC thoracic impedance. As discussed above, fluid accumulation may result from, among other things, pulmonary edema or pleural effusion, both of which may result from CHF.

In the example of FIG. 1, the system 100 also includes a controller 108. The controller 108 is typically a microprocessor or any other circuit that is capable of sequencing through various control states such as, for example, by using a digital microprocessor having executable instructions stored in an associated instruction memory circuit, a microsequencer, or a state machine. In this example, the controller 108 includes a digital signal processor (DSP) circuit 110. The digital signal processor circuit 110 performs any digital filtering or other signal processing needed to extract from the thoracic impedance signal a near-DC desired thoracic fluid amount signal. The digital signal processor circuit 110, therefore, may implement one or more filter circuits, and such filter circuits may be implemented as a sequence of executable instructions, rather than by dedicated filtering hardware.

However, the present inventors have recognized that the near-DC thoracic impedance signal is typically also affected by confounding factors other than the amount of fluid present in the thorax. One such confounding factor is any change in blood resistivity. Blood resistivity changes as a function of hematocrit in the blood. The hematocrit (Ht) or packed cell volume (PCV) is the proportion of blood that is occupied by red blood cells. It is typically between 0.35 and 0.52, and is slightly higher on average in males than in females. For example, when a patient is dehydrated, there will be less fluid in the patient's blood. Therefore, the patient's hematocrit level will increase, that is, the patient's blood will include a higher percentage of other components, such as insulative red blood cells. This will increase the blood resistivity, which, in turn, will affect the thoracic impedance signal even through it is not necessarily associated with the extravascular fluid accumulation of pulmonary edema or pleural effusion. Other factors that are believed to possibly influence blood resistivity include the patient's electrolyte level, certain medications in the blood, proteins in the blood, or blood gas concentrations.

As an illustrative example, the above change in hematocrit percentage from 35% to 52% may correspond to a change in resistivity from about 140 Ω·cm to about 200 Ω·-cm. Such changes in blood resistivity will influence the near-DC thoracic impedance measurement. This will confound an extravascular thoracic fluid amount determination using the near-DC thoracic impedance measurement, unless the extravascular thoracic fluid amount determination is corrected for such variations in blood resistivity, if any. Measurement of variations in blood resistivity is typically affected by the frequency of the excitation signal that are used. At higher excitation frequencies, blood cells typically become more resistive.

Accordingly, the system in FIG. 1 illustrates a blood resistivity measurement circuit 106. The blood impedance measurement circuit 106 receives a blood impedance measurement from electrodes that are associated with blood (and preferably blood in the thorax) such as in response to a delivery of test energy by a blood impedance test energy delivery circuit 112. In one example, the blood impedance measurement circuit 106 and the blood impedance test energy delivery circuit 112 are configured similar to the thoracic impedance measurement circuit 102 and the thoracic impedance test energy delivery circuit 104, respectively, as discussed above, except for being connected to different electrodes. Using the blood impedance measurement, the controller 108 executes a sequence of instructions to compute a blood resistivity correction 114. The blood resistivity correction 114 is applied to the thoracic fluid indication that is output by the digital signal processor circuit 110. This yields an adjusted thoracic fluid amount indication 116.

In FIG. 1, the thoracic impedance test energy delivery circuit 104 is illustrated separately from the blood impedance test energy delivery circuit 112 to assist the reader's conceptualization. In practice, these circuits, or portions thereof, may be combined. The combined circuit may be coupled to different electrodes for delivering the thoracic impedance test energy than for delivering the blood impedance test energy. Similarly, in FIG. 1, the thoracic impedance measurement circuit 102 is illustrated separately from the blood impedance test energy delivery circuit 112 to assist the reader's conceptualization. In practice, these circuits, or portions thereof, may be combined. The combined circuit may be coupled to different electrodes for measuring the responsive voltages for the thoracic and blood impedance measurements, as discussed below.

FIG. 2 is a schematic illustration of one example in which portions of the system 100 are implemented in an implantable cardiac rhythm management (CRM) or other implantable medical device (IMD) 200. In this example, the IMD 200 is coupled to a heart 202 using at least one leadwire, such as a multielectrode leadwire 204. In this example, the leadwire 204 includes a tip electrode 206, a distal ring electrode 208, and a proximal ring electrode 210, each of which is disposed in the right ventricle of the heart 202. In this example, each of the tip electrode 206, the distal ring electrode 208, and the proximal ring electrode 210 is independently electrically connected to a corresponding separate electrically conductive terminal within an insulating header 212. The header 212 is affixed to a housing 214 carrying electronic components of the IMD 200. In this example, the header 212 includes a header electrode 216, and the housing 214 includes a housing electrode 218.

In one example, thoracic impedance is sensed by delivering a test current between: (1) at least one of the ring electrodes 208 or 210; and (2) the housing electrode 218, and a resulting responsive voltage is measured across the tip electrode 206 and the header electrode 216. Because the IMD 200 is typically pectorally implanted at some distance away from the heart 202, this electrode configuration injects the test current over a substantial portion (but typically not the entire portion) of the patient's thorax, such that when the resulting voltage measurement is divided by the test current magnitude, it yields an indication of thoracic impedance. Using different electrodes for delivering the current and for measuring the responsive voltage reduces the component of the measured impedance signal that results from ohmic losses in the leadwires to the test current delivery electrodes. While such a “four-point” probe is useful, it is not required. In other examples, a “three-point probe” (having three electrodes, with one electrode used for both test current delivery and responsive voltage measurement), or a “two-point probe” (having two electrodes, each electrode used for both test current delivery and responsive voltage measurement) are used. Moreover, other electrode combinations could alternatively be used to implement a four-point probe. The above four-point probe description provides an illustrative example of one suitable four-point probe configuration.

In one example, blood impedance is sensed by delivering a test current between: (1) one of the distal ring electrode 208 or the proximal ring electrode 210; and (2) the housing electrode 218. A resulting responsive voltage is measured between: (1) the other of the distal ring electrode 208 or the proximal ring electrode 210; and (2) the tip electrode 206. In this example, although the test current is injected across a substantial portion of the patient's thorax, as discussed above, the responsive voltage signal of interest is measured across electrodes within the same chamber of the patient's heart (or, alternatively, within the same blood vessel). Therefore, when the responsive voltage measurement is divided by the test current magnitude, it yields an indication of the blood impedance in the heart chamber rather than the thoracic impedance. The measured blood impedance is used to compensate the measured thoracic impedance for changes in the blood impedance.

FIG. 3 is a block diagram illustrating generally another example in which portions of the system 100 are implemented in an implantable CRM or other IMD 300. The example of FIG. 3 includes an impedance test stimulus circuit 302 that, together with an impedance measurement circuit 304, provides thoracic and blood impedance measurements. In response to one or more control signals from the controller 108, an electrode configuration multiplexer 306 couples these circuits to the appropriate electrodes for the particular thoracic or blood impedance measurement. In this example, the multiplexer 306 is also coupled to a heart signal sensing circuit 308, which includes sense amplifier or other circuits for detecting from particular electrodes intrinsic electrical heart signals that include electrical depolarizations corresponding to heart contractions. The multiplexer 306 is also coupled to a therapy circuit 310, such as a pulse delivery circuit for delivering pacing, cardioversion, or defibrillation energy to particular electrodes in response to one or more control signals received from the controller 108.

In the example of FIG. 3, the DSP circuit 110 processes the thoracic impedance measurements from the impedance measurement circuit 304. The DSP circuit 110 extracts a cardiac stroke signal or a respiration signal from the thoracic impedance signal, such as by using techniques described in the above-incorporated Hartley et al. U.S. Pat. No. 6,076,015. One or both of the extracted cardiac stroke or respiration signals is provided to a blood impedance measurement synchronization circuit 312. The synchronization circuit 312 includes one or more peak-detector, level-detector, or zero-cross detector circuits to synchronize the blood impedance measurement to the same sample point of a cardiac contraction cycle or a respiration cycle. This reduces the effect of variations in one or both of these cycles on the blood impedance measurement. Similarly, the measurements can be taken under the same conditions with respect to posture or circadian cycle to reduce those effects on the blood impedance measurement. Posture can be detected using an accelerometer or other posture sensor; circadian cycle can be ascertained from a time-of-day indication provided by a clock circuit within the controller 108. Alternatively, the cardiac cycle information is extracted from the heart signal sensing circuit 308, either by itself or in combination with information from the controller 108 about when pacing or other stimulus pulses that evoke a responsive heart contraction are issued. The controller 108 computes an adjusted thoracic fluid indication 116 from the measured thoracic impedance. The adjusted thoracic fluid indication 116 is compensated for blood resistivity variations using the blood resistivity correction 114 obtained using the measured blood impedance. In a further example, the implantable medical device 300 includes a telemetry circuit 314 that communicates one of the blood-resistivity-compensated thoracic impedance or the blood resistivity and thoracic impedance measurements to an external programmer 316 or the like for further processing, storage, or display.

FIG. 4 is a flow chart illustrating generally one example of a method of providing a thoracic fluid amount indication that is compensated for any changes in blood resistivity. At 400, a thoracic impedance is detected. This may be accomplished in a number of different ways. In one illustrative example, such as described in Hartley et al. U.S. Pat. No. 6,075,015, it includes injecting a four-phase carrier signal, such as between a housing electrode 218 and a ring electrode 208. In this example, the first and third phases are +320 microampere pulses that are 20 microseconds long. The second and fourth phases are −320 microampere pulses that are 20 microseconds long. The four phases are repeated at 50 millisecond intervals to provide a carrier test current signal from which a responsive voltage can be measured. However, as discussed elsewhere in this document, because blood resistivity varies with excitation frequency, a different excitation frequency may also be used.

The Hartley et al. U.S. Pat. No. 6,075,015 describes an exciter circuit for delivering such a test current stimulus (however, the present system can alternatively use other suitable circuits, including an arbitrary waveform generator that is capable of operating at different frequencies or of mixing different frequencies to generate an arbitrary waveform). It also describes a signal processing circuit for measuring a responsive voltage between a housing electrode 216 and a tip electrode 206. In one example, the signal processing circuit includes a preamplifier, demodulator, and bandpass filter for extracting the thoracic impedance data from the carrier signal, before conversion into digital form by an A/D converter. Further processing is performed digitally, and is performed differently in the present system 100 than in the Hartley et al. U.S. Pat. No. 6,075,015.

For example, the Hartley et al. U.S. Pat. No. 6,075,015 includes a bandpass filter that receives the output of the A/D converter. The purpose of the highpass portion of the bandpass filter is to attenuate the near-DC portion of the thoracic impedance signal, which is the signal of interest to the present system 100. Therefore, the present system 100 eliminates the highpass filter. The cutoff frequency of the remaining lowpass filter is selected to pass the near-DC portion of the thoracic impedance signal and attenuate higher frequency portions of the thoracic impedance signal, including the respiration and cardiac stroke components of the thoracic impedance signal. In one example, a programmable cutoff frequency lowpass filter is used. In another example, an adaptive cutoff frequency lowpass filter is used, such that the cutoff frequency is moved to a higher frequency for higher values of heart rate and respiration frequency, and the cutoff frequency is moved to a lower frequency for lower values of heart rate and respiration frequency.

At 402 of FIG. 4, blood impedance is detected and measured. There are a number of ways in which this can be done. In one example, the blood impedance measurement is performed in the same manner as the thoracic impedance measurement, except that measurement of the responsive voltage is across two electrodes that are both typically located in the same heart chamber or same blood vessel, such as between (1) one of the distal ring electrodes 208 or the proximal ring electrode 210; and (2) the other of the distal ring electrode 208 or the proximal ring electrode 210. Because the blood impedance is to be used to correct a thoracic fluid indication, it is typically detected and measured at or near the thorax. Alternatively, however, even an external blood impedance measurement could be used, if desired. In one example, the blood impedance is sampled under appropriate other conditions (e.g., at a like point in different cardiac cycles, at a like point in different respiration cycles, etc.).

At 404, a thoracic fluid amount indication is determined. There are a number of ways in which this can be done. In one example, the thoracic fluid amount indication is given by the value of the near-DC thoracic impedance signal, which may be averaged or otherwise filtered, if desired. In another example, a baseline value of this averaged or otherwise filtered near-DC thoracic impedance signal is obtained from the patient, and the thoracic fluid amount indication is given by the difference of the near-DC thoracic fluid impedance value (with the same or different averaging or filtering) from this baseline value.

At 406, the thoracic fluid amount indication obtained from the near-DC thoracic impedance is adjusted to compensate for changes in blood resistivity. In one example, the adjusted thoracic fluid amount indication is given by: TFA_(adj)=TFA_(raw)·(ρ_(Blood, current))÷(ρ_(Blood, baseline)). In this equation, TFA_(adj) is the adjusted value of the thoracic fluid amount, (ρ_(Blood, baseline)) is the baseline value of the blood resistivity, and (ρ_(Blood, current)) is the current value of the blood resistivity. In the present case, since the same electrodes are used for both the baseline and current blood resistance measurements, the resistivity ratio (ρ_(Blood, current))÷(ρ_(Blood, baseline)) is given by the corresponding ratio of the blood resistances, i.e., (Z_(Blood, current))÷(Z_(Blood, baseline)).

In a further example, such as where the implantable medical device 300 optionally includes a posture sensor or detector 318, a separate baseline impedance or resistivity is provided for different postures, since posture affects thoracic impedance measurements. In one example, a separate baseline impedance or resistivity is stored for upright postures (e.g., sitting or standing) than for recumbent postures (e.g., supine, prone, left lateral decubitus, right lateral decubitus). In a further example, a separate baseline impedance or resistivity is stored for one or more of the different subtypes of upright or recumbent postures. In compensating the thoracic fluid amount indication, the posture compensation module 320 compensates a particular resistivity measurement by using a baseline resistivity that corresponds to the then-current posture indicated by the postures detector 318. One example of a suitable posture detector 318 is a commercially available two-axis accelerometer, such as Model No. ADXL202E, manufactured by Analog Devices, Inc. of Norwood, Mass., USA.

The compensated thoracic fluid amount indication can be stored in the implantable medical device 300 or transmitted to the external device 316. Moreover, in one example, the implantable medical device 300 or external device 316 is capable of storing a history of the values of the thoracic fluid amount indication to assist the physician in managing the CHF state of the patient. In one example, the external device 316 is capable of displaying a graph, histogram or other chart of such thoracic fluid amount values.

In a further example, the implantable medical device 300 or the external device 316 determines whether heart failure decompensation, pulmonary edema, or pleural effusion is present, such as by comparing an increase in the blood-resistivity-compensated thoracic fluid amount indication to a corresponding first threshold value to deem one or more of these conditions to be present.

In yet a further example, the implantable medical device 300 or the external device 316 predicts whether heart failure decompensation, pulmonary edema, or pleural effusion is likely to become present in the future, such as by comparing an increase in the blood-resistivity-compensated thoracic fluid amount indication to a corresponding second threshold value to deem one or more of these conditions to be likely in the future. The second threshold used for the condition prediction may be different from the first threshold used for the condition detection. In one example, the second threshold value reflects a smaller increase in the thoracic fluid amount indication than the first threshold value.

In yet a further example, the implantable medical device 300 adjusts a therapy to the patient using the thoracic fluid amount indication. In one example, an increase in the thoracic fluid amount indication triggers an increase in a rate at which pacing pulses are delivered to the heart. In another example, a change in the thoracic fluid amount indication results in altering another programmable parameter of cardiac pacing or cardiac resynchronization therapy, such as, for example, atrioventricular (AV) delay, particular cardiac stimulation sites, interventricular delay, or intraventricular delay. In a further example, a change in the thoracic fluid amount indication triggers the providing of a warning or other indication to the patient to adjust a medication level (for example, a diuretic).

Another application for the present systems, devices, and methods is in anemia detection. Anemia is a pathological condition that is often present in CHF patients. Diagnosing and treating anemia will improve a patient's cardiac function. Therefore, there is a need to detect anemia in CHF patients, for example, to communicate a diagnosis regarding the anemia status to a CHF patient's health care provider.

FIG. 5 is a flow chart illustrating generally one example of an anemia detection method. At 500, a baseline blood impedance is established. In one example, this includes obtaining one or more near-DC blood impedance measurements (typically taken within the same blood vessel or heart chamber) such as described above with respect to 402 of FIG. 4. In one example, the baseline blood impedance is established by computing a central tendency (e.g., average, median, low-pass filtered, etc.) value of a series of such measured blood impedances over a desired time interval (for example, one month).

At 502, a current blood impedance is measured. This near-DC blood impedance measurement is typically performed in the same manner and location as described above for establishing the baseline. At 504, the current blood impedance is compared to the baseline blood impedance. As described above, a higher percentage of red blood cells tends to increase blood impedance. Therefore, when the current blood impedance falls far enough below the baseline blood impedance, then anemia may be indicated. Therefore, in one example, if the current blood impedance falls below the baseline blood impedance by at least an offset threshold value, then anemia is declared to be present at 506. In one example, the offset value is a fixed or programmable percentage of the baseline blood impedance (e.g., 5%, 10%, 20%, etc.). The offset value is typically set to prevent normal physiological variations in blood impedance from triggering an anemia detection. In another example, such as by choosing a different threshold value, the comparison predicts that anemia is likely to occur (e.g., if the blood impedance falls at least 10% below its baseline value, then future anemia is predicted; if the blood impedance then falls at least 20% below its baseline value, then present anemia is declared).

In one further example, if anemia is predicted or declared present, that information is telemetered or otherwise communicated to the patient's health care provider from the implantable medical device, such as by providing such information to an external device for storage or display. In one example, such communication takes place the next time that the implantable medical device is interrogated by a programmer or other external interface. In another example, such the implantable medical device itself initiates a telemetric or other communication of such information to an external device. In yet a further example, an anemia warning is provided to the patient, either directly by the implantable medical device (e.g., an audible warning), or via an external interface device.

As discussed above, measurement of variations in blood resistivity is typically affected by the frequency of the excitation signal that are used. At higher excitation frequencies, blood cells typically become more resistive. Therefore, to yield a more sensitive measurement of anemia, it may be desirable to use a higher excitation frequency than would be used for detecting thoracic impedance, and for correcting the resulting thoracic impedance measurements for changes in blood resistivity. Alternatively, such as for measuring thoracic fluid status, if a change in blood resistivity exceeds a certain threshold value then, in one example, the system automatically switches to a lower excitation frequency that is affected less by changes in blood resistivity.

Although much of the above discussion has emphasized correcting near-DC thoracic impedance measurements to account for changes in blood resistivity, hematocrit-related blood resistivity changes may also affect higher frequency components of the thoracic impedance signal (e.g., respiration components, cardiac stroke components, etc.), somewhat analogous to the way in which patient posture can affect such higher frequency components of the thoracic impedance signal. Aspects of the present blood resistivity measurement and correction techniques may also be used for correcting such higher-frequency components of the thoracic impedance signal. However, the effects of blood resistivity changes at higher frequency may be nonlinear, making correction with a single multiplicative correction factor difficult or impossible. Therefore, a nonlinear correction function may be used, if needed. Such a nonlinear correction function may be empirically determined. In one example, the nonlinear correction function may be implemented as a lookup table. Moreover, the higher-frequency components of the thoracic impedance signal may be used to infer thoracic fluid status even much of the above discussion focused on particular examples that extract a thoracic fluid status signal from the near-DC component of the thoracic impedance signal.

It is to be understood that the above description is intended to be illustrative, and not restrictive. For example, the above-described embodiments (and/or aspects thereof) may be used in combination with each other. Many other embodiments will be apparent to those of skill in the art upon reviewing the above description. The scope of the invention should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. In the appended claims, the terms “including” and “in which” are used as the plain-English equivalents of the respective terms “comprising” and “wherein.” Also, in the following claims, the terms “including” and “comprising” are open-ended, that is, a system, device, article, or process that includes elements in addition to those listed after such a term in a claim are still deemed to fall within the scope of that claim. Moreover, in this document and in the following claims, the terms “first,” “second,” and “third,” etc. are used merely as labels, and are not intended to impose numerical requirements on their objects. 

1. A method comprising: detecting a thoracic impedance signal of a thorax of a subject; detecting a blood resistivity signal; and determining a thoracic fluid indication using the thoracic impedance signal, the determining the thoracic fluid indication including using the blood resistivity signal to reduce or eliminate an effect of a change in the blood resistivity on the thoracic fluid indication.
 2. The method of claim 1, further comprising filtering the thoracic impedance signal to obtain a near-DC thoracic impedance signal, and in which the thoracic fluid indication is generated at least in part by using the near-DC thoracic impedance signal.
 3. The method of claim 2, in which the filtering the thoracic impedance signal includes attenuating or removing frequency components above about 0.05 Hz.
 4. The method of claim 2, in which the filtering the thoracic impedance signal includes attenuating or removing a cardiac stroke component of the thoracic impedance signal.
 5. The method of claim 2, in which the filtering the thoracic impedance signal includes attenuating or removing a respiration component of the thoracic impedance signal.
 6. The method of claim 2, in which the filtering the thoracic impedance signal includes attenuating or removing a posture component of the thoracic impedance signal.
 7. The method of claim 2, in which the filtering the thoracic impedance signal includes using a variable lowpass cutoff frequency filter.
 8. The method of claim 1, in which the detecting the thoracic impedance signal and the determining the thoracic fluid indication are performed using an implantable medical device.
 9. The method of claim 1, in which the detecting the thoracic impedance signal comprises: delivering a test current from first and second implantable electrodes; and measuring a resulting voltage in response to the test current from third and fourth implantable electrodes.
 10. The method of claim 9, in which at least one of the first and second implantable electrodes is the same electrode as the third and fourth implantable electrodes.
 11. The method of claim 9, in which the first and second implantable electrodes are different electrodes from the third and fourth implantable electrodes.
 12. The method of claim 9, in which the delivering the test current includes delivering a carrier signal.
 13. The method of claim 1, in which the detecting the thoracic impedance signal includes using at least one cardiovascular electrode.
 14. The method of claim 1, in which the detecting the thoracic impedance signal includes using at least one electrode located on a housing of an implantable medical device.
 15. The method of claim 1, in which the detecting the thoracic impedance signal includes using at least one electrode located on a substantially electrically insulating header of an implantable medical device.
 16. The method of claim 1, in which the detecting the blood resistivity signal includes using first and second intravascular electrodes.
 17. The method of claim 1, in which the detecting the blood resistivity signal includes: delivering a test current between first and second electrodes, in which the first and second electrodes are both located within single heart chamber or blood vessel; and measuring a resulting voltage in response to the test current.
 18. The method of claim 1, in which the detecting the blood resistivity includes measuring a volume of blood that is substantially independent of a degree of fluid present in the thorax.
 19. The method of claim 1, in which the detecting the blood resistivity includes measuring the blood resistivity at like times during at least one of a cardiac cycle and a respiratory cycle.
 20. The method of claim 1, in which the determining a thoracic fluid indication using the thoracic impedance signal includes: measuring a first thoracic impedance value at a first time; measuring a first blood resistivity value at a second time that is close to the first time; measuring a second thoracic impedance value at a third time; and measuring a second blood resistivity value at a fourth time that is close to the third time; and normalizing, using the first and second blood resistivity values, the second thoracic impedance value to the first thoracic impedance value.
 21. The method of claim 20, in which the normalizing includes multiplying the second thoracic impedance value by a ratio of the first and second blood resistivity values.
 22. The method of claim 1, in which the determining a thoracic fluid indication using the thoracic impedance signal includes: measuring a baseline first blood resistivity value; measuring a first thoracic impedance value and a corresponding second blood resistivity value; and computing a second thoracic impedance value using the first thoracic impedance value and the first and second blood resistivity values.
 23. The method of claim 22, in which the computing the second thoracic impedance value includes multiplying the first thoracic impedance value by a ratio of the first blood resistivity value to the second blood resistivity value.
 24. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and determining whether heart failure decompensation is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 25. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and predicting heart failure decompensation using the history of the thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 26. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and determining whether pulmonary edema is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 27. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and predicting pulmonary edema using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 28. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and determining whether pleural effusion is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 29. The method of claim 1, further comprising: storing a history of thoracic fluid measurements; and predicting pleural effusion using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 30. The method of claim 1, further including transmitting information about the thoracic fluid indication from an implantable medical device to an external device.
 31. The method of claim 30, further including displaying the information about the thoracic fluid indication on the external device.
 32. The method of claim 30, further including storing the information about the thoracic fluid indication in the external device.
 33. The method of claim 1, further including providing therapy to the subject, the therapy determined at least in part using the thoracic fluid indication.
 34. The method of claim 1, in which the using the blood resistivity signal to reduce or eliminate an effect of a change in the blood resistivity on the thoracic fluid indication includes: measuring a posture of the patient; storing a first baseline blood resistivity corresponding to a first posture; storing a second baseline blood resistivity corresponding to a second posture that is different from the first posture; and compensating the thoracic fluid indication by selecting and using the one of the first and second baseline blood resistivities that corresponds to the then-current posture of the patient.
 35. The method of claim 34, in which the first posture is an upright posture and the second posture is a recumbent posture.
 36. A method of using an implantable medical device, the method comprising: detecting a thoracic impedance signal of a thorax of a subject using implantable electrodes to deliver a test current and measure a responsive voltage; detecting a blood resistivity signal, within a heart chamber or blood vessel, from a volume of blood that is substantially independent of a cardiac cycle and a respiratory cycle; filtering the thoracic impedance signal to substantially remove frequency components above 0.05 Hz to obtain a near-DC thoracic impedance signal; and determining a thoracic fluid indication using the thoracic impedance signal, the determining the thoracic fluid indication including compensating the thoracic impedance signal for changes in blood resistivity.
 37. The method of claim 36, in which the compensating comprises multiplying a thoracic impedance signal value by a ratio of a baseline blood resistivity to a blood resistivity measured close in time to a time when the thoracic impedance signal value was measured.
 38. The method of claim further comprising: storing a history of thoracic fluid measurements; and determining whether at least one of heart failure decompensation, pulmonary edema, and pleural effusion is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 39. A system comprising: an implantable medical device, including: a thoracic impedance measurement circuit, to provide a thoracic impedance signal; a blood resistivity measurement circuit, to provide a blood resistivity signal; and a controller, coupled to the blood resistivity measurement circuit, the controller operable to determine a thoracic fluid indication using the filtered thoracic impedance signal, including using the blood resistivity signal to reduce or eliminate an effect of a change in the blood resistivity on the thoracic fluid indication.
 40. The system of claim 39, in which the thoracic impedance measurement circuit includes: a test current circuit to deliver a test current to first and second implantable electrodes; and a voltage measurement circuit to measure a resulting voltage between third and fourth implantable electrodes.
 41. The system of claim 40, further including the at least one of the first and second implantable electrodes and at least one of the third and fourth implantable electrodes, and in which at least one of the first and second implantable electrodes is the same electrode as the third and fourth implantable electrodes.
 42. The system of claim 40, further including the at least one of the first and second implantable electrodes and at least one of the third and fourth implantable electrodes, and in which the first and second implantable electrodes are different electrodes from the third and fourth implantable electrodes.
 43. The system of claim 40, in which the test current circuit includes a carrier signal generator circuit.
 44. The system of claim 39, further including at least one cardiovascular leadwire electrode to detect the thoracic impedance signal.
 45. The system of claim 39, in which the implantable medical device includes a housing, and in which the housing includes at least one electrode to detect the thoracic impedance signal.
 46. The system of claim 45, in which implantable medical device includes at least one substantially electrically insulating header attached to the housing, and in which the header includes at least one electrode to detect the thoracic impedance signal.
 47. The system of claim 39, further comprising first and second cardiovascular electrodes to detect the blood resistivity signal.
 48. The system of claim 47, in which the first and second cardiovascular electrodes are arranged with respect to each other to be disposed within the same heart chamber or blood vessel.
 49. The system of claim 47, further including a sense amplifier to detect intrinsic heart signals corresponding to each cardiac cycle of a subject, and in which the blood resistivity measurement circuit includes a synchronization circuit to synchronize blood resistivity measurements to at least one of (1) like phases of different cardiac cycles; and (2) like phases of different respiration cycles.
 50. The system of claim 39, further including a frequency selective filter circuit, to receive the thoracic impedance signal, the frequency selective filter circuit providing a near-DC filtered thoracic impedance signal.
 51. The system of claim 50, in which the filter circuit includes a lowpass filter circuit including at least one lowpass pole at a frequency of about 0.05 Hz.
 52. The system of claim 50, in which the filter circuit includes a lowpass filter circuit including at least one lowpass pole at a frequency that attenuates or removes a cardiac stroke component of the thoracic impedance signal.
 53. The system of claim 50, in which the filter circuit includes a lowpass filter circuit including at least one lowpass pole at a frequency that attenuates or removes a respiration component of the thoracic impedance signal.
 54. The system of claim 50, in which the filter circuit includes a lowpass filter circuit including at least one variable-frequency lowpass pole.
 55. The system of claim 39, further comprising: a posture sensor, to provide a posture signal; and a posture compensation module, operable to compensate the thoracic fluid indication using the posture signal.
 56. The system of claim 55, in which the posture compensation module includes different baseline blood resistivity measurements corresponding to different postures.
 57. The system of claim 39, in which the controller includes: a first memory location to store a first thoracic impedance value measured at a first time; a second memory location to store a first blood resistivity value measured at a second time that is close to the first time; a third memory location to store a second thoracic impedance value measured at a third time; and a fourth memory location to store a second blood resistivity value measured at a fourth time that is close to the second time; and a normalization module to normalize, using the first and second blood resistivity values, the second thoracic impedance value to the first thoracic impedance value.
 58. The system of claim 57, in which the normalization module includes an arithmetic logic unit (ALU) that multiplies the second thoracic impedance value by a ratio of the first and second blood resistivity values.
 59. The system of claim 39, in which the controller circuit includes: an averaging circuit to measure a first blood resistivity value; a first memory location to store a first thoracic impedance value; a second memory location to store a second blood resistivity value that corresponds to the first thoracic impedance value; and in which the controller circuit is operable to compute a second thoracic impedance value using the first thoracic impedance value and the first and second blood resistivity values.
 60. The system of claim 59, in which the controller includes a multiplier circuit to multiply the first thoracic impedance value by a ratio of the first blood resistivity value to the second blood resistivity value.
 61. The system of claim 39, further comprising: a memory configured to store a history of thoracic fluid measurements; and a heart failure decompensation detection or prediction module operable to determine whether heart failure decompensation is present or likely to occur using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 62. The system of claim 61, in which the memory and the decompensation detection or prediction module are located in the implantable medical device.
 63. The system of claim 61, in which the memory and the decompensation detection or prediction module are located in an external device.
 64. The system of claim 39, further comprising: a memory configured to store a history of thoracic fluid measurements; and a pulmonary edema detection or prediction module operable to determine whether pulmonary edema is present or likely to occur using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 65. The system of claim 64, in which the memory and the pulmonary edema detection or prediction module are located in the implantable medical device.
 66. The system of claim 64, in which the memory and the pulmonary edema detection or prediction module are located in an external device.
 67. The system of claim 39, further comprising: a memory configured to store a history of thoracic fluid measurements; and a pleural effusion detection or prediction module operable to determine whether pleural effusion is present or likely to occur using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 68. The system of claim 67, in which the memory and the pleural effusion detection or prediction module are located in the implantable medical device.
 69. The system of claim 67, in which the memory and the pleural effusion detection or prediction module are located in an external device.
 70. The system of claim 39, further including an external device operable to be communicatively coupled to the implantable medical device to receive information about the thoracic fluid indication from the implantable medical device.
 71. The system of claim 70, in which the external device includes a display device to display the information about the thoracic fluid indication.
 72. The system of claim 70, in which the external device includes a storage device to store the information about the thoracic fluid indication.
 73. The system of claim 39, further including a therapy circuit, coupled to the controller, the therapy circuit operable to provide a therapy to a subject, the therapy determined at least in part using the thoracic fluid indication from the controller.
 74. A system comprising: an implantable medical device, including: a thoracic impedance measurement circuit, to provide a thoracic impedance signal; a frequency-selective filter circuit, coupled to the thoracic impedance measurement circuit to receive the thoracic impedance signal, the frequency selective filter circuit including at least one lowpass pole providing a near-DC filtered thoracic impedance signal, the at least one lowpass pole substantially attenuating or removing at least one of a heart contraction component and a respiration component of the thoracic impedance signal; a blood resistivity measurement circuit, to provide a blood resistivity signal from which a blood resistivity measurement is obtained, the blood resistivity measurement being substantially independent of a variation resulting from heart contractions, respiration, and degree of thoracic fluid; and a controller, coupled to the filter circuit and the blood resistivity measurement circuit, the controller operable to determine a thoracic fluid indication using the filtered thoracic impedance signal, including using the blood resistivity signal to reduce or eliminate an effect of a change in the blood resistivity on the thoracic fluid indication, the thoracic fluid indication determined by multiplying a thoracic impedance signal value by a ratio of a baseline blood resistivity to a blood resistivity measured close in time to a time when the thoracic impedance signal value was measured.
 75. The system of claim 74, further comprising: a memory storage device operable to store a history of thoracic fluid measurements; and means for determining whether at least one of heart failure decompensation, pulmonary edema, and pleural effusion is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 76. A system comprising: an implantable medical device, including: a thoracic impedance measurement circuit, to provide a thoracic impedance signal; a frequency selective filter circuit, coupled to the thoracic impedance measurement circuit to receive the thoracic impedance signal, the frequency selective filter circuit providing a near-DC filtered thoracic impedance signal; a blood resistivity measurement circuit, to provide a blood resistivity signal; means for determining a thoracic fluid indication using the filtered thoracic impedance signal; and means for reducing or eliminating an effect of a change in blood resistivity on the thoracic fluid indication.
 77. The system of claim 76, further comprising: a memory storage device operable to store a history of thoracic fluid measurements; and means for determining whether at least one of heart failure decompensation, pulmonary edema, and pleural effusion is present using the history of thoracic fluid measurements to determine whether a change in thoracic fluid has occurred.
 78. A method comprising: detecting a first blood resistivity at a first time using at least one implanted intravascular or intracardiac electrode in a patient; detecting a second blood resistivity at a second time using the at least one implanted intravascular or intracardiac electrode; comparing the second blood resistivity to the first blood resistivity; and if the second blood resistivity is less than the first blood resistivity by at least a threshold value, then declaring an indication or prediction of anemia to be present in the patient.
 79. The method of claim 78, in which the detecting the first blood resistivity and the detecting the second blood resistivity are performed in the same blood vessel or heart chamber.
 80. The method of claim 78, in which the detecting the first blood resistivity and the detecting the second blood resistivity are performed under like conditions with respect to at least one of a cardiac cycle, a respiratory cycle, a posture, and a circadian cycle.
 81. The method of claim 78, further comprising communicating an indication of anemia predicted or anemia present to an external device.
 82. A system comprising: an implantable medical device, including: first and second electrodes located within the same blood vessel or heart chamber; a blood resistivity measurement circuit, to provide a blood resistivity signal obtained between the first and second electrodes at different first and second times; and a controller, coupled to the blood resistivity measurement circuit, the controller operable to determine an indication or prediction of anemia by comparing a current blood resistivity to a stored baseline blood resistivity value.
 83. The system of claim 82, in which the blood resistivity measurement circuit includes: a test current circuit to deliver a test current to first and second implantable electrodes; and a voltage measurement circuit to measure a resulting voltage between third and fourth implantable electrodes.
 84. The system of claim 82, further comprising a heart signal sensing circuit configured to synchronize the first and second times to like portions of different cardiac cycles.
 85. The system of claim 82, further comprising a thoracic impedance measurement circuit configured to synchronize the first and second times to like portions of different respiration cycles.
 86. The system of claim 82, further comprising a posture sensor and a posture compensation module configured to store different baseline blood resistivities corresponding to different postures obtained from the posture sensor. 